XWH - 12 - 2 - 0126 TITLE : Development and Efficacy Testing of Next Generation Cyanide Antidotes
نویسنده
چکیده
منابع مشابه
XWH - 08 - 2 - 0126 TITLE : Developing Memory Reconsolidation Blockers as Novel PTSD Treatments
متن کامل
A novel paradigm for assessing efficacies of potential antidotes against neurotoxins in mice.
Historically, antidotal potencies of cyanide antagonists were measured as increases in the experimental LD(50) for cyanide elicited by the antidotes. This required the use of high doses of cyanide following pre-treatment with the putative antidote. Since IACUC guidelines at our institutions strongly discourage LD(50) determinations: we developed a new test paradigm that allowed for maximal surv...
متن کاملCisplatin Analogs Confer Protection against Cyanide Poisoning.
Cisplatin holds an illustrious position in the history of chemistry most notably for its role in the virtual cure of testicular cancer. Here we describe a role for this small molecule in cyanide detoxification in vivo. Cyanide kills organisms as diverse as insects, fish, and humans within seconds to hours. Current antidotes exhibit limited efficacy and are not amenable to mass distribution requ...
متن کاملAppropriate Utilization and Stocking of Antidotes in Qatar Public Hospitals
Background: There are a few studies that evaluate preparedness and availability of antidotes in the emergency setting and none have been conducted in Qatar. Published studies show that timely availability of antidotes in the emergency department setting is a common issue. To address this, we conducted a study to evaluate antidote stocking and utilization in Qatar hospital pharmacies and emergen...
متن کاملChemical and metabolomic screens identify novel biomarkers and antidotes for cyanide exposure.
Exposure to cyanide causes a spectrum of cardiac, neurological, and metabolic dysfunctions that can be fatal. Improved cyanide antidotes are needed, but the ideal biological pathways to target are not known. To understand better the metabolic effects of cyanide and to discover novel cyanide antidotes, we developed a zebrafish model of cyanide exposure and scaled it for high-throughput chemical ...
متن کامل